Information on PDT English Version... Photodynamic Therapy (PDT) What is it?
PDT utilizes a light sensitive medicine which selectively accumulates on diseased tissue.
Light of specific wavelengths is then applied to the affected area.
How does it work? Why does it work?
1. Light-activated agent (photosensitizer) administered
2. Agent accumulates selectively in affected tissue
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Tumor Before Agent
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Agent Selectively attaches to Tumour |
An approved diagnostic tool 
Karl Storz PDD set
| | Squamous cancer on floor of mouth
Before |
After agent tumour fluorescence |
Squamous cancer right vocal cord
Before After agent tumour fluorescence | |
Accumulation on Breast Cancer
|
Accumulation on ovarian cancer in incision
| |
Light is applied to affected area
|
A non toxic effective treatment for primary and metastatic cancer and other diseases
| |
4. Agent becomes activated, creating singlet oxygen
5. Singlet oxygen destroys diseased cells, leaving normal tissue largely unaffected
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Following light administration tumour cells are damaged or destroyed
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Tumour cells (orange)
24 hours after light
| 
Tumour cells (orange)
72 hours after light showing
massive cell death
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| Agent also accumulates in new vessels feeding tumour After light treatment blood flow coagulates 
Blood clots in vessels feeding tumour |
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Fragmentation of tumour cells causes immune system to produce tumour specific anti-bodies (auto vaccination)
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Why does it work?
Why do photosensitizers concentrate in tumour cells?
Tumour cells have a lactic acid metabolism and have a negative charge
Photosensitizers precipitate in acid environments and are positively charged
Tumour cells have a lactic acid metabolism and have a negative charge
Normal Cell Malignant Cell
Photosensitizers precipitate in acid environments and are positively charged
How does the combination of light sensitive agent and light kill or damage cancer cells?
What does it treat?
Cancer and certain eye diseases are the primary indications for PDT at present. Many other medical conditions are helped by Photodynamic Therapy
Additional medical indications
Psoriasis
Vascular disease
Rheumatoid arthritis
Skin cancer
Acne
Warts
Gynecological |
Barratts esophagus
Viral
Bacterial
Fungal
HIV
AIDS
Periodontal & Dental |
An effective therapy for head and neck cancer
Before |
After Therapy |
Before After Therapy
| 1 Week 2 Weeks | 
Endoscopically delivered PDT is an FDA approved therapy for
esophageal and lung cancer
| 3 Weeks 6 Weeks | |
An effective therapy for age related macular degeneration (leaky type) of the eye
| | 
Early Stage | 
Late Stage (leakage) | |
In clinical trials for the treatment of atherosclerosis and restenosis following coronary artery balloon angioplasty
Before After | | 
Before | 
After Treatment | |
Skin Cancer
| |
Warts
| |
Gynecological
Condyloma acuminata (warts)
| | 
Before
| 
After
| | Before
| 
3 Months
| 48 Hours
|
Viral Herpes simplex
Herpes zoster
Hepatitis C, D
Papilloma
| Bacterial Gram positive bacteria
MRSA (methacillin resistant staph areus) | |
HIV
| |
AIDS - related Kaposis sarcoma
| | 
Before
| 
After
| | Fungal
Tinea pedis
Tinea cruris
Chronic fungal infection of nail beds
Many recalcitrant fungal infections have likewise been shown to be benefited by Next Generation PDT/PDT
What is the scientific proof of effectiveness?
Google
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A laser treatment option for oral and throat cancers
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Photodynamic Therapy for Cancer: Questions and Answers, Cancer ...
Date reviewed: 5/12/2004. Photodynamic Therapy for Cancer: Questions and Answers.
Key Points. ... What is photodynamic therapy? Photodynamic therapy ...
cis.nci.nih.gov/fact/7_7.htm - 17k - 21 Feb 2005 - Cached - Similar pages
What is the scientific proof of effectiveness?
What is the scientific proof of effectiveness?
PubMed
All: 2814
Items 1 - 20 of 141Next 1: Wolfsen HC.Related Articles, Links Present Status of Photodynamic Therapy for High-Grade Dysplasia in Barrett's Esophagus.
Items 1 - 20 of 141Next Show: NCBI | NLM | NIH Department of Health & Human Services
What is the scientific proof of effectiveness?
The New England Journal of Medicine
Search Criteria
Search In: All Medline Anywhere in Article: pdt From: Jan 1995 through: Feb 2005 [ New search ] [ Save Search to Personal Archive ]
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[Clinical study of photodynamic therapy for laryngeal cancer] T Yoshida, T Saeki, S Ohashi, T Okudaira, M Lee, H Yoshida, H Maruoka, H Ito, S Funasaka, and H Kato Nippon Jibiinkoka Gakkai Kaiho, May 1995; 98: 795-804. Case reports [Abstract]
[View Next 20 Results]
Search Criteria
Search In: All Medline Anywhere in Article: pdt From: Jan 1995 through: Feb 2005 [ New search ] [ Save Search to Personal Archive ]
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Typical Treatment
Evaluation by physician
Medicine administered
Have Light treatments
Repeat cycles as directed by physician
Any Side effects?
Treatment Protocol Step 1: The physician completes a medical evaluation and determines the appropriate amount of light sensitive medicine for the patient.
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Step 2: The appropriate amount of light sensitive medicine is given to the patient orally over 2-3 days
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Step 3: Patients wait 24 to 36 hours for the agent to clear from skin and normal tissue
 
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Step 4: To activate light sensitive medicine
you will be given treatment with a
Whole-body Illumination
D evice (WID) for three to five days following administration of the Next Generation Photosensitizer (PhotoNexGen).
| |
Side Effects
At the recommended dosage only a small number of patients may experience noticeable undesirable effects.
In most patients these symptoms were minor and lasted only for a short while.
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